Structure of β-cinnamomin, a protein toxic to some plant species

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Toxic fibrillar oligomers of amyloid-β have cross-β structure.

Although amyloid fibers are found in neurodegenerative diseases, evidence points to soluble oligomers of amyloid-forming proteins as the cytotoxic species. Here, we establish that our preparation of toxic amyloid-β(1-42) (Abeta42) fibrillar oligomers (TABFOs) shares with mature amyloid fibrils the cross-β structure, in which adjacent β-sheets adhere by interpenetration of protein side chains. W...

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Ethnobotanical Study of Medicinal Plants and Introduction to Some Poisonous Plant Species of Ardestan (Isfahan Province)

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Bioequivalence & Bioavailability of the Phytoconstituents in Some Plant Species Potentially Toxic

The ancolies are regarded as dangerous (seeds). The alkaloids which they contain bring closer aconitine but their toxicity is definitely less. Their extreme acridness generally avoids poisonings. The plant’s seeds and roots are highly poisonous however, and contain cardiogenic toxins which cause both severe gastroenteritis and heart palpitations if consumed as food. Folk medicine used very smal...

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ژورنال

عنوان ژورنال: Acta Crystallographica Section D Biological Crystallography

سال: 2002

ISSN: 0907-4449

DOI: 10.1107/s0907444902010107